Integrated assessment of CT-derived fibrosis volume and pulmonary function in identifying progressive pulmonary fibrosis in connective tissue disease-associated interstitial lung disease (CTD-ILD)

This study evaluated the integrated assessment of CT-derived fibrosis volume and pulmonary function tests to identify progressive pulmonary fibrosis (PPF) in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD). Fibrosis volume was quantitatively measured from CT images using AVIEW Lung Texture (Coreline Soft), and combined with pulmonary function parameters including FVC and DLCO to construct a PPF prediction model. The integrated assessment of CT-derived fibrosis volume and pulmonary function demonstrated superior accuracy in identifying PPF compared to either measure alone. This combined approach may have clinical utility in early risk stratification of disease progression in CTD-ILD patients and in determining the optimal timing for initiating antifibrotic therapy.