Texture-Based Automated Quantitative Assessment of Regional Patterns on Initial CT in Patients With Idiopathic Pulmonary Fibrosis: Relationship to Decline in Forced Vital Capacity

Hyo Jung Park, Sang Min Lee, Jin Woo Song, Sang Min Lee, Sang Young Oh, Namkug Kim, Joon Beom Seo
American Journal of Radiology, 2016
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Lung Texture

Date Published
2016. 11

In this retrospective study, the objective was to identify predictive factors for a decline in forced vital capacity (FVC) based on initial CT scans using texture-based automated quantification in patients with idiopathic pulmonary fibrosis (IPF). The study included 193 IPF patients with 1-year follow-up pulmonary function tests. A texture-based automated system was used to quantify six regional CT patterns: normal, ground-glass opacity (GGO), reticular opacity (RO), honeycombing, emphysema, and consolidation. A decline in FVC was defined as a decrease of more than 10% in the initial FVC. The results showed that a decline in FVC occurred in 32 patients, with the extent of RO being the only independent predictor for this decline. A receiver operating characteristic (ROC) analysis indicated that an RO extent of less than 22.05% accurately predicted stable IPF at the 1-year follow-up in terms of FVC. The concept of the research has been comercialized in AVIEW Lung Texture, Coreline Soft.


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