Coronary calcium score and emphysema extent on different CT radiation dose protocols in lung cancer screening

Authors
Roberta Eufrasia Ledda, Gianluca Milanese, Maurizio Balbi, Federica Sabia, Camilla Valsecchi, Margherita Ruggirello, Andrea Ciuni, Giulia Tringali, Nicola Sverzellati, Alfonso Vittorio Marchianò & Ugo Pastorino
Journal
European Radiology
Related Product

CAC

Date Published
2024.12
Summary

This study, published by the University of Parma team, investigated the feasibility of automated quantification of coronary artery calcification (CAC) and emphysema using low-dose (LDCT) and ultra-low-dose (ULDCT) CT scans in lung cancer screening. A total of 361 participants underwent scans analyzed with AVIEW software. The CAC measurements showed high agreement between LDCT and ULDCT (ICC = 0.86) with an overlap rate of 84%. In contrast, emphysema measurements exhibited moderate agreement (ICC = 0.57) and a tendency for overestimation on ULDCT. The findings demonstrate that ULDCT is suitable for CAC quantification and suggest the potential expansion of low-dose lung cancer screening into cardiovascular disease prevention. This study highlights the applicability of AVIEW software for CAC quantification even on ULDCT protocols.

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