This study, known as the Korean Lung Cancer Screening Project (K-LUCAS), was a single-arm cohort study conducted from February 2017 with the aim to evaluate the feasibility of implementing a national lung cancer screening program in Korea. The study targeted a high-risk population aged 55–74 years with more than a 30-pack-year smoking history. The results of the screening were reported using the Lung Imaging Reporting and Data System (Lung-RADS), as recommended by the American College of Radiology. To maintain the quality of the screening, K-LUCAS used a network-based diagnostic supporting system with a computer-aided detection (CAD) program, specifically AVIEW LCS nodule detection AI developed by Coreline Soft. (This software was not directly mentioned in the paper but was used for the process.) The study found that among the 5,692 eligible high-risk participants, 865 had positive screening results requiring further examination and 42 had confirmed lung cancer. The results of K-LUCAS provide encouraging evidence supporting the implementation of a national lung cancer screening program to detect early stage lung cancer and promote smoking cessation among participants in the Asian population.