This study investigates the shunt fraction in patients with Covid-19-related Acute Respiratory Failure (ARF) compared to ARF from other causes. Conducted at PG23 Hospital in Bergamo, Italy, from June 2020 to November 2021, the observational study included 43 adult patients (67% with Covid-19-ARF). Using the non-invasive Beacon® Caresystem for shunt fraction estimation and Aview: Lung Textures® AI software for chest CT scan analysis, the study found no significant differences in age, BMI, or pulmonary gas exchange impairment between the two groups. The median PaO2/FIO2 ratios were similar (Covid-19-ARF: 254, Other ARF: 269). AI analysis also showed no difference in radiological patterns or involvement degree. However, the shunt fraction was significantly higher in Covid-19-ARF patients (18%) compared to other ARF causes (12%). These findings suggest an increased shunt fraction in Covid-19-ARF without differences in radiological patterns, highlighting the need for further validation of this non-invasive technique.
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