Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

This study examined the impact of long-term exposure to PM10 and NO2 on lung function and imaging phenotypes in a cohort of Korean participants, including those with and without COPD. The cohort consisted of 457 participants, with 296 diagnosed with COPD, sourced from the COPD in Dusty Areas (CODA) cohort. Annual average concentrations of PM10 and NO2 were estimated at participants' residences using a spatial air pollution prediction model. Participants underwent volumetric CT, spirometry measurements, and completed questionnaires. Linear regression models, adjusted for various factors, were used to assess associations of PM10 and NO2 with lung function and imaging measurements. Using the Aview® system (Coreline Soft Inc., Seoul, South Korea), functional small airway disease was calculated from CT images. Results showed that higher PM10 exposure was significantly associated with lower FVC, higher emphysema index, and higher wall area percent. No significant associations were observed with NO2 exposure.