Treatment Response Evaluation by Computed Tomography Pulmonary Vasculature Analysis in Patients With Chronic Thromboembolic Pulmonary Hypertension

Yu-Sen Huang, Zheng-Wei Chen, Wen-Jeng Lee, Cho-Kai Wu, Ping-Hung Kuo, Hsao-Hsun Hsu, Shu-Yu Tang, Cheng-Hsuan Tsai, Mao-Yuan Su, Chi-Lun Ko, Juey-Jen Hwang, Yen-Hung Lin, Yeun-Chung Chang
Korean Journal of Radiology
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In this study, researchers evaluated the pulmonary vasculature of 30 chronic thromboembolic pulmonary hypertension (CTEPH) patients using non-contrast computed tomography (CT) before and after treatment. They correlated CT-based parameters with right heart catheterization (RHC) hemodynamic and clinical parameters. Leveraging the Aview® system (Coreline Soft, Inc.) for lung segmentation and pulmonary vasculature analysis, the researchers found significant increases in the number, area, and density of subpleural small vessels post-treatment. Additionally, blood volume shifted from larger to smaller vessels, and the BV5/TBV ratio correlated with hemodynamic and clinical parameters. The study highlights the effectiveness of non-contrast CT measures, aided by the Aview® software, in evaluating changes in pulmonary vasculature in response to treatment.


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